Tocotrienols - A Gem in the Vitamin E Family

Tocotrienols are members of the Vitamin E family with up to 60 times more powerful antioxidation properties in lipid biological systems than alpha-tocopherol (1). Cellular uptake of tocotrienols is up to 70 times higher, as its distinct chemical structure readily allows rapid absorption by body cells and organs (2).

Tocotrienols as powerful antioxidants protect the body from attack by free radicals and DNA damage. A randomized, double-blinded, placebo-controlled study with 64 subjects aged 37─78 years old showed a significant reduction of DNA damage in their blood samples after 3 months of 160 mg daily dose of tocotrienols and the positive effects continued to the end of the trial at 6 months (3).

Cellular Wellness Beyond Antioxidation

Far beyond its antioxidation properties, over 400 research studies have established that tocotrienols provide unique health benefits for cellular wellness, cardiovascular and metabolic health, liver health, skin care, neuroprotection and anti-inflammation.

Tocotrienols are not just simple antioxidants. Multiple research studies have shown that tocotrienols, even at low doses, have powerful anti-cancer properties not found in alpha- tocopherol. Tocotrienols were found to:

• cause apoptosis or cell death in prostate, breast, skin, pancreas, liver and colon cancer cells, while leaving normal cells healthy (4)
• inhibit blood vessel formation (angiogenesis) which can help inhibit tumour development (5)
• reduce the propensity of cancer cells to spread (metastasis) (6).

A study by DavosLife published in the International Journal of Cancer (July 2010) showed that gamma-tocotrienols could kill prostate cancer stem cells unaffected by docetaxel, an anti-cancer drug. Cancer stem cells are believed to be involved in the initiation and recurrence of cancer. In the study, DavosLife also showed that pre-treatment with gamma-tocotrienols prevented prostate cancer from developing in 75% of mice as compared to 100% tumour formation in the control group (7).

Cardiovascular and Metabolic Health

Tocotrienols help maintain cardiovascular and metabolic health by promoting lipid (fat) balance through triglyceride and LDL cholesterol reduction by up to 25% (8). In in vitro studies, animal models and a clinical trial, DavosLife showed that tocotrienol reduced the production and transport of triglycerides in the body, thereby reducing triglyceride levels by 28% (9). Another clinical study has shown that tocotrienol supplementation inhibited atherosclerosis or fatty plaque formation in main blood vessels suggesting their role in promoting cardiovascular health (10). In addition, in a recent double-blind placebo-control human study, 69% of the patients with non-alcoholic fatty liver disease (NAFLD) on tocotrienols showed improvement in their fatty liver conditions as compared to 33% in the placebo group (11).

Neuroprotection

Various published studies by scientists at the Ohio State University Medical Center show that alpha-tocotrienol, but not alpha-tocopherol, has neuroprotective properties at a nanomolar (parts per billion) concentration. Their scientists stated that, “this represents the most potent of all biological functions exhibited by any natural vitamin E molecule” (12).

Anti-inflammation

The NF-kappaB transcription factor is a central player in the regulation of inflammation and immune responses. Consequently, problems with NF-kappaB regulation have been implicated in the development of diverse forms of diseases including autoimmune diseases and certain cancers. As reported by scientists from the University of Texas MD Anderson Cancer Center, gamma-tocotrienol suppresses NF-kappaB activation while gamma-tocopherol has no effect. According to scientists from the center their “results demonstrate that gamma-tocotrienol is a potent inhibitor of NF-kappaB activation, which may explain its anti-angiogenic, anti-proliferative, proapoptotic, antimetastatic, anti-inflammatory, and immunomodulatory effects.” Moreover, they pointed out that their “data are in agreement with other published reports that tocotrienol is a superior molecule among the members of the family of Vitamin E” (13).

Radioprotection

In vivo animal studies, including a number of published studies by researchers from the U.S. Armed Forces Radiobiology Research Institute (AFRRI) at the Uniformed Services University of the Health Sciences that show that gamma- and delta-tocotrienols are able to provide good recovery and survivability for mice exposed to high doses of total body irradiation (14,15). Their studies also showed that gamma- and delta-tocotrienols were able to protect the haematopoietic stem cells that produce all types of blood cells by preventing DNA damage (15,16). Other researchers also showed in animal studies that gamma-tocotrienol protects against gastrointestinal and vascular injury from total-body irradiation (17).

These statements have not been evaluated by the Food and Drug Administration Exposure to ionizing radiation or radiation contaminants can cause injuries in the bone marrow, blood vessels, immune system, gastrointestinal tract and the central nervous system, including damage to cell DNA that leads to increased risks of cancers. There are few accepted remedies for radiation exposure, other than consumption of iodine to prevent the accumulation of radioactive iodine in vulnerable structures such as the thyroid gland.

However, there are various in vitro and. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your doctor before taking this product if you have any health condition or are taking any medication.

Naturaleł Full Spectrum Tocotrienols

DavosLife Naturaleł Full Spectrum Tocotrienols contains a balanced full spectrum formula of all 4 natural tocotrienol isomers (alpha, beta, gamma and delta). This 100% natural tocotrienol complex is gamma-tocotrienol rich, with no artificial additives or preservatives added. Naturaleł is extracted using state-of-the-art technology from GMO-free palm fruits fully traceable to the plantations of its parent company, the Kuala Lumpur Kepong Berhad Group (RSPO certified). Naturaleł is granted the Generally Regarded As Safe (GRAS) status by the FDA.

Naturaleł Bio-Enhanced 20 For Better Absorption

Naturaleł Bio-Enhanced 20 the epitome of the SEDDS (self-emulsifying delivery systems)formula that gives at least 2 times higher bio-availability than competition. Upon ingestion, Naturaleł Bio-Enhanced 20 forms micro/nano emulsion in the gut which enables high absorption into the body and reduces breakdown in the liver, independent of dietary fat or food intake. Davos Life Science R&D validated that Naturaleł Bio-Enhanced 20 delivers tocotrienol at consistently much higher levels than current commercially available product.

Naturaleł Bio-Enhanced 20 will be the preferred formula for brand owners and manufacturers of dietary supplements as it enables the full benefits of tocotrienol to be achieved for all health concerns via its optimized delivery.

References

1 Serbinova E, Kagan V, Han D & Packer L. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha tocotrienol. Free Radic Biol Med 1991;10(5).

2 Saito Y, Yoshida Y, Nishio K, et al. Characterization of cellular uptake and distribution of vitamin E. Ann N Y Acad Sci 2004;1031.

3 Chin SF, Hamid NA, Latiff AA, et al. Reduction of DNA damage in older healthy adults by Tri E Tocotrienol supplementation. Nutrition 2008;24(1).

4 Aggarwal BB, Sundaram C, Prasad S & Kannappan R. Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol 2010; 80(11).

5 Miyazawa T, Inokuchi H, Hirokane H, et al. Anti-angiogenic potential of tocotrienol in vitro. Biochemistry (Mosc) 2004;69(1).

6 Yap WN, Chang PN, Han HY, et al. Gamma-tocotrienol suppresses prostate cancer cell proliferation and invasion through multiple-signalling pathways. Br J Cancer 2008;99(11). 7 Luk SU, Yap WN, Chiu Y-T, et al. Gamma-tocotrienol as an effective agent in targeting prostate cancer stem cell-like population. Int J Cancer 2010.

8 Qureshi AA, Sami SA, Salser WA & Khan FA. Dose-dependent suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans. Atherosclerosis 2002;161:199.

9 Zaiden N, Yap WN, Ong S, et al. Gamma delta tocotrienols reduce hepatic triglyceride synthesis and VLDL secretion. J Atheroscler Thromb 2010;17(10).

10 Kooyenga DK, Watkins TR, Geller M, et al. Antioxidants modulate the course of carotid atherosclerosis: a four year report. In K. Nesaretnam and L. Packer (Ed.). Micronutrients and health: Molecular biological mechanisms. Illinois, IL: AOCS Press.

11 Magosso EA, Yogheswaran MA, Rizal G, et al. Tocotrienols and NFALD: A Clinical Experience. Paper presented at The 61st Annual Meeting of the American Association for the Study of Liver Disease (AASLD) 2010.

12 Sen CK, Khanna S & Roy S. Tocotrienols: Vitamin E beyond tocopherols. Life Sci 2006;78(18).

13 Aggarwal BB & Ahn KS. Targeting Inflammation for Prevention and Treatment of Cancer by Tocotrienols: Food for Thought. PIPOC 2007.

14 Gosh SP, Kulkarni S, Hieber K, et al. Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector. Int J Radiat Biol 2009;85(7):598-606.

15 Kulkarni S, Ghosh SP, Satyamitra M, et al. Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total body irradiation. Radiat Res 2010; 173(6):738-47.

16 Satyamitra MM, Kulkarni S, Ghosh SP, et al. Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform ä-Tocotrienol. Radiat Res 2011. (Epub Ahead of Print)

17 Berbee M, Fu Q, Boerma M, Wang J, Kumar KS and Hauer-Jensen M. Gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. Radiat Res 2009;171(5):596-605.